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. 2020 May 8;27:61. doi: 10.1186/s12929-020-00656-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Exogenous TGR5 agonist INT777 ameliorated brain injury at 24 h and 72 h after MCAO. Representative TTC staining indicated brain infarction at 24 h and 72 h after MCAO (a, e);quantified infarct ratio(b, f), neurological scores (c, g) and brain water content(d, h) showed that INT777 decreased infarction and neurological deficits in medium dose as well as reduced brain edema of right ischemic hemisphere at 24 h and 72 h after MCAO . High dose was only analyzed at 24 h after MCAO. n = 6 for each group. *P < 0.05 vs sham, ^#P < 0.05 vs MCAO+ vehicle. Bars represent mean ± SEM. BS indicates brain stem; CB, cerebellum; LH, left hemisphere; RH, right hemisphere