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The effect of INT777 and siRNA on TGR5 and BRCA1 expression in penumbra after middle cerebral artery occlusion (MCAO). a, b Double immunofluorescence staining showed that expression of TGR5 or BRCA1 was upregulated in the penumbra area 24 h after MCAO; INT777 treatment increased the expressions while siRNA inhibited TGR5 or BRCA1 expression. n = 6 per group. *P < 0.05 vs sham, #P < 0.05 vs MCAO+ vehicle. Bars represent mean ± SEM. Scale bar, 50 μm
