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. 2020 May 8;27:61. doi: 10.1186/s12929-020-00656-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The effect of knockdown TGR5 on BRCA1/Sirt1 expression and BBB permeability after MCAO. a The band of Western blot analysis; b The relative density of TGR5, BRCA1, Sirt1.n = 6 per group. TGR5 or BRCA1 knockout increased infarct volume (c), worsen neurobehavioral deficits (d), exacerbated brain water content (e) and BBB permeability (f). n = 6 per group. *P < 0.05 vs sham, ^#P < 0.05 vs MCAO+ Scr siRNA. Bars represent mean ± SEM. Scr siRNA, scramble siRNA