Table 1.
Baseline cardiac characteristics of Sham and HF rats
| Sham (n = 10) |
HF (n = 10) |
|
|---|---|---|
| Body weight: BW (g) | 356 ± 6 | 370 ± 7 |
| Heart weight: HW (g) | 1.2 ± 0.1 | 1.6 ± 0.1* |
| HW/BW * 1000 | 3.2 ± 0.1 | 4.3 ± 0.2* |
| Infarct size (% of endocardial LV) | 0 | 39 ± 2* |
| LVEDP (mmHg) | 3 ± 1 | 21 ± 3* |
| LVESP (mmHg) | 119 ± 4 | 106 ± 3 |
| Heart rate (bpm) | 350 ± 14 | 361 ± 14 |
| +dP/dt (mmHg/s) | 7161 ± 584 | 4783 ± 281* |
| −dP/dt (mmHg/s) | − 6878 ± 552 | − 3745 ± 172* |
| LVEDD (mm) | 8.0 ± 0.2 | 10.4 ± 0.2* |
| LVESD (mm) | 4.8 ± 0.1 | 8.5 ± 0.2* |
| Fractional shortening (%) | 39 ± 1 | 18 ± 1* |
| Ejection fraction (%) | 64 ± 1 | 33 ± 1* |
| LVEDV (μl) | 428 ± 27 | 653 ± 45* |
| LVESV (μl) | 151 ± 14 | 443 ± 39* |
| Stroke volume (μl) | 277 ± 14 | 209 ± 10* |
| Cardiac output (μl/min) | 105 ± 2 | 66 ± 3* |
Values are mean ± SEM; n = 10 for each group of rats. LVEDP, left ventricular end-diastolic pressure
LVESP left ventricular end-systolic pressure, +dP/dt maximal slope of systolic pressure increment. −dP/dt maximal slope of diastolic pressure decrement, LVEDD left ventricular end-diastolic dimension, LVESD left ventricular end-systolic dimension, LVEDV left ventricular end-diastolic volume, LVESD left ventricular end-systolic volume
*P < 0.05 compared to Sham