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. 2020 May 7;20:157. doi: 10.1186/s12935-020-01238-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Differential expression pattern and clinical outcome of TCGA ccRCC patients in the two different clusters. a Consensus clustering cumulative distribution function (CDF) for k = 2–9; b relative change in area under CDF curve for k = 2–9; c Principal component analysis of the total RNA expression profile in the TCGA ccRCC cohort; d The survival analysis for the two clusters by Kaplan–Meier method; e Heatmap and clinicopathologic features of the two clusters defined by the m⁶A RNA methylation regulators consensus expression. *p < 0.05, **p < 0.01, ***p < 0.001