Figure 6.

Mechanisms of genotoxicity of azoxymethane. Direct biological effect of methylating agent, azoxymethane, results in O6-meG. The methylated G–T mismatch can form A-T, resulting in G:C to A:T transitions, or may be repaired by methyl transferase. Recombination repair may involve the homologous recombination or non-homologous end joining pathways. Indirect effects through formation of 8-OHdG due to increased oxidative stress may result in C to A transversions or may be repaired by excision. O6-MeG: O6-methyl guanosine, 8-OHdG: 8-hydroxy deoxyguanosine