Table 1.
Inhibitory effect of phytate on AOM-induced aberrant crypt foci and tumor incidence in Fisher 344 male rat colon
| Treatment | Incidence of ACF (%) | ACF/colon | Crypt multiplicity of ACF | Tumor incidence | ||||
|---|---|---|---|---|---|---|---|---|
| 1 crypt | 2 crypts | 3 crypts | ≥4 crypts | Non-invasive (%) | Invasive (%) | |||
| Control | 0/8 (0) | — | — | — | — | — | — | — |
| AOM | 20/20(100) | 386± 38 | 125± 14 | 165± 15 | 58± 6 | 38± 4 | 14(58.3) | 10(41.6) |
| AOM + 1% Phytate | 20/20 (100) | 218± 19* | 87± 8* | 92± 9* | 32± 4* | 7± 2* | 3 | — |
| AOM + 2% Phytate | 20/20(100) | 146± 12** | 47± 5** | 62± 6** | 22± 3** | 5± 2* | — | — |
NOTE: Data are shown as mean±SD of 20 samples in each group.
*P<0.001, vs AOM (Bonferroni T test). AOM: Azoxymethane, ACF: Aberrant crypt foci