Table 4.

Effect of crocin and ethanol (Et) on histopathological changes in liver and kidney tissues of rat after 4 weeks treatment. Histopathological criteria were determined semi-quantitatively from mild (+) to moderate (++) and sever (+++), n=6

Groups	Liver	Kidney
Control	Normal	Normal
Ethanol (5 g/kg – 50% v/v)	Severe congestion (+++), steatosis (+++) and portal lymphocytic infiltration (++)	Proteinuria (++) and infiltration of inflammatory factors around glomerular (++)
Crocin 10 mg/kg + ethanol	Moderate congestion (++), steatosis (+) and portal lymphocytic infiltration (+)	Proteinuria (+) and infiltration of inflammatory factors around glomerular (+)
Crocin 20 mg/kg + ethanol	Mild congestion (+)	Normal
Crocin 20 mg/kg	Normal	Normal
Crocin 40 mg/kg + ethanol	Severe congestion (+++), steatosis (+) and portal lymphocytic infiltration (++)	Proteinuria (++) and infiltration of inflammatory factors around glomerular (+)
Crocin 40 mg/kg	Mild congestion (+) and portal lymphocytic infiltration (+)	Proteinuria (+) and infiltration of inflammatory factors around glomerular (+)