Figure 6.

Defects in trachea, larynx and palate were observed in R184P homozygous mice. (A) Larynges of the homozygous embryos fail to open during development. In wild-type and heterozygous embryos, the larynx is open from E13.5. The trachea of the homozygous embryos remains atretic at all examined stages. The trachea of wild-type and heterozygous embryos are patent by E17.5 (n ≥ 14 per stage). (B) The secondary palate of the homozygous embryos does not fuse. Palatal defects are not observed in wild-type and heterozygous embryos (n ≥ 14 per stage). Data are presented at E14.5 and E17.5. Lr, larynx; Tr, trachea. Green arrows, typical organ development. Red arrows, deviation from the norm or presence of defect.