Table 2.

Association results for SNPs in the PVRL2 gene in the German chip data sets (A) and replication of the finding for rs6859 in the Danish longevity sample (B)

			Without conditioning			Conditionede
SNP	MAFa LLI	MAFa Controls	P CCA b	ORc	95% C.I.d	P CCA b	ORc	95% C.I.d
A Germans
1. Illumina Immunochip data set (46)
rs6859	0.400	0.432	0.000792	0.8669	0.798–0.942	0.205	0.944	0.864–1.032
2. Affymetrix® Genome-Wide Human SNP Array 6.0 data set (45)
rs4081918	0.094	0.079	0.116	1.208	0.955–1.528	0.089	1.231	0.969–1.564
rs11879589	0.093	0.079	0.137	1.197	0.945–1.516	0.106	1.220	0.959–1.552
rs11672399	0.070	0.058	0.167	1.211	0.923–1.589	0.088	1.275	0.964–1.686
rs519113	0.237	0.218	0.188	1.109	0.951–1.293	0.124	1.131	0.967–1.324
rs7255063	0.388	0.394	0.662	0.970	0.848–1.110	0.465	0.948	0.820–1.095
rs8104483	0.267	0.271	0.755	0.977	0.842–1.133	0.469	0.945	0.811–1.101
rs17561351	0.055	0.053	0.762	1.047	0.779–1.407	0.485	1.114	0.822–1.510
rs2927466	0.238	0.233	0.802	1.020	0.874–1.191	0.701	1.031	0.881–1.206
rs12610605	0.169	0.166	0.820	1.021	0.855–1.218	0.833	0.979	0.807–1.188
B Danes
rs6859	0.389	0.436	0.013	0.8193	0.700–0.959	0.239	0.903	0.762–1.070

Listed are allele frequencies, allelic P-values, odds ratios and the 95% confidence intervals.

^aMinor allele frequency, MAF; the definition of the minor allele is based on controls.

^bAllelic P-values, PCCA; calculated with chi-squared (χ2)-test with one degree of freedom.

^cOdds ratio for longevity, OR; based on the minor allele in controls.

^d95% confidence interval, 95% C.I.; C.I. for the odds ratio.

^eConditioned for rs2075650 (Immunochip) and rs4420638 for the Affymetrix data set (45, 46), respectively; conditioned for rs2075650 in the Danish.