Table 5.
Genotypes frequencies of tested polymorphisms according to common adverse effects of isotretinoin treatment.
| Parameter | rs2241766 | P value | rs1501299 | P value | ||||
|---|---|---|---|---|---|---|---|---|
| GG, number (%) | TG, number (%) | TT, number (%) | GG, number (%) | GT, number (%) | ||||
| Joint pain | Yes | 2 (0.9) | 43 (19.5) | 122 (55.5) | 0.708 | 87 (39.5) | 80 (36.4) | 0.926 |
| No | 0 (0.0) | 13 (5.9) | 40 (18.2) | 28 (12.7) | 25 (11.4) | |||
|
| ||||||||
| Mucosal dryness/nose bleed | Yes | 1 (0.5) | 32 (14.5) | 89 (40.5) | 0.948 | 65 (29.5) | 57 (25.9) | 0.739 |
| No | 1 (0.5) | 24 (10.9) | 73 (33.2) | 50 (22.7) | 48 (21.8) | |||
|
| ||||||||
| Headache | Yes | 0 (0.0) | 33 (15.0) | 91 (41.4) | 0.255 | 70 (31.8) | 54 (24.5) | 0.158 |
| No | 2 (100) | 23 (41.1) | 71 (43.8) | 45 (20.5) | 51 (23.2) | |||