Table 3.
Details of clinical trials conducted with curcumin nanoformulations.
| S. No | Clinical trials.gov identifier | Study title | Status | Applications against disease | Responsible for investigation |
|---|---|---|---|---|---|
| 1 | NCT01403545 | Evaluation of liposomal curcumin in healthy volunteers | Completed | Drug safety | Medical University of Vienna, Vienna, Austria |
| 2 | NCT01925547 | Micellar curcumin and metabolic syndrome biomarkers | Completed | Metabolic syndrome | University of Hohenheim, Germany |
| 3 | NCT01201694 | Study on surface controlled water soluble curcumin | Completed | Cancer | UT MD Anderson Cancer Center Houston, Texas, United States |
| 4 | NCT03150966 | The immunomodulatory effects of oral nanocurcumin in multiple sclerosis patients | Completed | Multiple sclerosis | Tabriz University of Medical Sciences, Iran |
| 5 | NCT03140657 | The effects of nanocurcumin on treg cells and Th17 cells responses in ankylosing spondylitis patients | Completed | Ankylosing spondylitis | Tabriz University of Medical Sciences, Iran |
| 6 | NCT01982734 | Improved oral bioavailability of curcumin incorporated into micelles | Completed | Drug safety | University of Hohenheim, Germany |
| 7 | NCT03534024 | The effects of nanomicelles curcumin on glycemic control, serum lipid profile, blood pressure, and anthropometric measurements in patients with metabolic syndrome | Recruiting | Metabolic syndrome | National Nutrition And Food Technology Research Institute, Iran |
| 8 | NCT03514667 | The effects of nanocurcumin on serum oxidative stress inflammation, adiponectin, and NF-kB in blood mononuclear cells in metabolic syndrome patients (Nuclear Factor-κB) | Recruiting | Metabolic syndrome | National Nutrition and Food Technology Research Institute, Tehran, Iran |
| 9 | NCT01294072 | Study investigating the ability of plant exosomes to deliver curcumin to normal and colon cancer tissue | Active, not recruiting | Colon cancer tissue | University of Louisville, United States |
| 10 | NCT02724618 | Nanocurcumin for prostate cancer patients undergoing radiotherapy (RT) | Active, not recruiting | Prostate cancer | Shahid Beheshti University of Medical Sciences, Iran |
| 11 | NCT01001637 | Efficacy and safety of curcumin formulation in Alzheimer’s disease | Unknown | Alzheimer’s disease | Jaslok Hospital and Research Centre, Maharashtra, India |
| 12 | NCT02683759 | Bio-enhanced curcumin as an add-on treatment in maintaining remission of ulcerative colitis | Unknown | Ulcerative colitis | Asian Institute of Gastroenterology, Hyderabad, India |
Source: Clinical trials information obtained from U.S. National Library of Medicine clinical trial (https://clinicaltrials.gov/) website