Figure 3.
SOX9 regulates BCL2L1 and CASP3 in undifferentiated CRC cell lines. Quantitative RT-qPCR showed that, after SOX9 silencing, BCL2L1 and CASP3 did not change in well-differentiated (a) normal CCD-18Co and (b) HT-29 cell lines, but a tendency similar to HCT-116 was seen in the moderate-differentiated SW-480 (c). However, these changes were not statistically significant. For SOX9 silencing in all cell lines, ∗p < 0.01.