Figure 1.

(A) Baseline circulating CXCL14 (C-X-C motif chemokine ligand-14) concentrations in girls with polycystic ovary syndrome (PCOS, n=52) and in healthy age-matched controls (n=21). Data are mean±SD. ^*P=0.007, for patients versus controls at baseline. (B) Longitudinal results of CXCL14 serum concentrations in girls with PCOS who received an oral contraceptive (OC, white circles, n=16) or low-dose spironolactone, pioglitazone, and metformin (SPIOMET, black circles, n= 15). The dotted line is the mean in healthy controls (n=21); the shaded area represents the mean±SD in those healthy controls. *P=0.004, for patients versus controls at baseline; §p=0.02, on treatment differences between controls and the OC subgroup; #p=0.01, for changes 0–1 year in the SPIOMET subgroup; &p=0.04 for changes 0–1 year between the OC subgroup and the SPIOMET subgroup.