Table 3.
Logistic regression analyses to assess the association between variables and severe hypoglycemia in people with type 2 diabetes on insulin
| Variable | OR (95% CI) Crude analysis |
OR (95% CI) Model 1 |
OR (95% CI) Model 2 |
OR (95% CI) Model 3 |
| Caucasian ethnicity | 0.72 (0.58–0.89) | 0.72 (0.58–0.90) | 0.75 (0.60–0.96) | 0.69 (0.54–0.88) |
| Clinical care (secondary/tertiary) | 1.29 (1.06–1.57) | 1.28 (1.05–1.56) | 1.16 (0.93–1.44) | 0.92 (0.72–1.16) |
| Complex insulin regimen | 1.81 (1.43–2.29) | 1.80 (1.42–2.28) | 1.64 (1.27–2.12) | 1.44 (1.07–1.94) |
| Use of sulfonylureas | 0.63 (0.47–0.86) | 0.64 (0.47–0.87) | 0.68 (0.50–0.95) | 0.88 (0.60–1.27) |
| Use of metformin | 0.75 (0.63–0.89) | 0.74 (0.62–0.88) | 0.75 (0.62–0.91) | 0.76 (0.62–0.93) |
| Pronounced polypharmacy | 1.45 (1.20–1.75) | 1.48 (1.22–1.78) | 1.40 (1.15–1.71) | 1.22 (0.97–1.54) |
| Use of psychoactive drugs | 1.58 (1.29–1.93) | 1.58 (1.29–1.94) | 1.54 (1.24–1.91) | 1.37 (1.08–1.75) |
| History of cardiovascular disease | 1.33 (1.11–1.61) | 1.37 (1.13–1.65) | 1.26 (1.03–1.54) | 1.17 (0.95–1.45) |
Statistically significant data (p<0.05) appear in boldface type. Model 1 is adjusted for age and sex. Model 2 is adjusted for age, sex, HbA1c and diabetes duration. Model 3 is adjusted for age, sex, HbA1c, diabetes duration and diabetes duration and for all other variables mentioned in table 2. Complex insulin regimen: a regimen consisting of pre-mixed insulin or combination of short-acting and intermediate- or long-acting insulin.