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Frequency of alterations of commonly mutated genes in metastatic renal cell carcinoma (mRCC). (A) VHL, PBRM1, SETD2 and BAP1 are among the most frequently mutated gene mutations in this mRCC cohort and exhibited a high degree of concomitant mutations. (B) A small subset of patients were found to harbor three concurrently altered genes. (C) Mutation frequency of frequently altered mRCC genes did not correlate clinical response.
