Figure 1.

Mast cell recruitment is impaired when PDE3 is targeted. (A) Representative photographs of toluidine blue (arrows pointed to mast cells) stained lung section obtained from phosphate buffered saline (PBS) control mice and house dust mite (HDM) driven asthmatic mice. (B) Number of epithelial mast cells (MCs) per mm length basal membrane. A Kruskal-Wallis test for multiple comparisons was used, followed by a Mann-Whitney U test. Error bars show mean values ± SEM (n=3 for PBS, n=6 for HDM groups; **P < 0.01; ***P < 0.005). Data are representative for three independent experiments.