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. 2020 Apr 30;26:e920668-1–e920668-14. doi: 10.12659/MSM.920668

Figure 6.

Figure 6

The expression of pyroptosis-associated proteins in the study groups in the rat model of sepsis induced by cecal ligation and puncture (CLP). Male Sprague-Dawley rats (n=120) were divided into six study groups: the sham group; the CLP group; the hemin group (treated with ferric chloride and heme); the zinc protoporphyrin IX (ZnPPIX) group; the CO-releasing molecule 2 (CORM-2) group; and the inactive CORM-2 (iCORM-2) group. The expression of pro-caspase-1, pro-caspase-11, caspase-1 p20, caspase-11 p20, and gasdermin D (GSDMD) in the intestinal mucosa. β-actin was used as an internal control. (A) Western blot results for pro-caspase-1, pro-caspase-11, caspase-1 p20, caspase-11 p20, and GSDMD in the intestinal mucosa. (B) The relative level of pro-caspase-1 expression. (C) The relative level of pro-caspase-11 expression. (D) The relative level of GSDMD expression. (E) The relative level of caspase-1 p20 expression. (F) The relative level of caspase-11 p20 expression. The bars represent the mean±SE (n=3~5). * P<0.05 versus the sham group. # P<0.05 versus the CLP group. CLP – cecal ligation and puncture; CORM-2 – CO-releasing molecule 2; Hemin – ferric chloride heme; ZnPPIX – zinc protoporphyrin IX; iCORM-2 – inactive CORM-2.