Table 3.
Summary of Survey Results for Clinicians Who Are Currently Using (First Number) PG and Clinicians Who Are Not Currently Using PG But Are Interested in Integration of PG into Clinical Practice (Second Number) for Specific Drug-Gene Pairs Across 8 Different Services
| Gene | Medication | Cardiology | Psychiatry | Pain | Infectious Diseases | Oncology | Transplant | Primary Care | Neurology | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PharmD (n=9) | MD (n=8) | PharmD (n=5) | MD (n=9) | PharmD (n=9) | MD (n=11) | PharmD (n=12) | MD (n=5) | PharmD (n=7) | MD (n=9) | PharmD (n=16) | MD (n=11) | PharmD (n=12) | MD (n=16) | PharmD (n=6) | MD (n=4) | ||
| CYP2C9/ VKORC1 | Warfarin | 0/3 | 0/3 | 1/6 | 0/8 | 0/3 | 1/0 | ||||||||||
| CYP2C9/ HLA-B | Phenytoin | 1/4 | 1/2 | ||||||||||||||
| CYP2C19/CYP2D6 | Sertraline/Citalopram/ Escitalopram/Paroxetine/ Fluoxetine/Fluvoxamine | 1/2 | 2/6 | 1/5 | 0/10 | ||||||||||||
| Imipramine/Doxepin/ Amitriptyline/Clomipramine | 0/3 | 0/6 | 0/4 | 2/6 | 0/6 | 0/5 | |||||||||||
| CYP2C19 | Clopidogrel | 0/3 | 0/4 | 0/4 | 0/0 | ||||||||||||
| Voriconazole | 4/5 | 3/1 | 0/3 | 1/1 | |||||||||||||
| Pantoprazole/Omeprazole/ Lansoprazole | 0/3 | 0/8 | |||||||||||||||
| CYP2D6 | Codeine/Oxycodone | 0/4 | 3/7 | 0/3 | 1/1 | 2/5 | 2/3 | 1/5 | 0/9 | ||||||||
| Venlafaxine | 1/2 | 0/6 | 0/4 | 2/7 | |||||||||||||
| Tramadol | 0/2 | 1/6 | 0/1 | 0/1 | 1/5 | 0/7 | |||||||||||
| Tamoxifen | 0/2 | 0/0 | |||||||||||||||
| Risperidone/Aripiprazole/ Haloperidol | 1/3 | 1/5 | |||||||||||||||
| Propafenone/Flecainide | 0/3 | 0/3 | |||||||||||||||
| Mirtazapine | 0/3 | 0/6 | 0/5 | 0/6 | |||||||||||||
| Atomoxetine | 0/2 | 0/5 | |||||||||||||||
| Ondansetron | 0/4 | 2/6 | 0/3 | 1/2 | 0/5 | 0/3 | |||||||||||
| TPMT | Mercaptopurine/ Azathioprine | 0/2 | 6/1 | ||||||||||||||
| DPYD | Fluorouracil/Capecitabine | 0/4 | 0/0 | ||||||||||||||
| CYP3A5 | Tacrolimus | 0/3 | 0/0 | 5/7 | 2/7 | ||||||||||||
| SLCO1B1 | Simvastatin | 0/1 | 0/2 | 0/6 | 0/7 | ||||||||||||
| G6PD | Rasburicase | 0/2 | 2/1 | ||||||||||||||
| HLA-B | Carbamazepine | 1/3 | 1/2 | 1/4 | 1/2 | ||||||||||||
| Abacavir | 4/3 | 4/1 | 1/4 | 3/0 | |||||||||||||
| Allopurinol | 0/2 | 1/1 | 0/5 | 1/0 | |||||||||||||
| UGT1A1 | Atazanavir | 0/2 | 1/1 | 0/5 | 0/8 | ||||||||||||
| Irinotecan | 1/4 | 1/2 | |||||||||||||||