Prados‐Torres 2017.

Methods	Cluster‐RCT
Participants	Inclusion: 65 to 74 years, multi‐morbidity (3 or more chronic diseases), polypharmacy (5 or more drugs taken for at least 3 months), at least 1 visit to family physician in past year, agree to participate and provide written informed consent Exclusion: institutionalised at nursing home or similar, life expectancy < 12 months, mental and/or physical conditions considered by family physician to prevent fulfilment of study requirements
Interventions	Intervention: family physicians receive training related to multi‐morbidity, appropriateness of prescribing, treatment adherence, Ariadne principles, and physician‐patient shared decision‐making. Then physicians conduct physician‐patient interviews based on Ariadne principles including structured review of treatment plan, inclusion of patient preferences, and a pharmacological treatment plan Control: usual care
Outcomes	Medication adherence using Morisky‐Green questionnaire and Haynes‐Sackett questionnaire, health‐related quality of life (EQ‐5D‐5L), use of health services (hospitalisations, emergency services, and primary care), medication safety (incidence of adverse drug reactions), and cost utility (time spent on training family physicians, cost of teaching staff, time spent on physician‐patient interviews, utilities measured using the EuroQol‐5D‐5L)
Notes	NCT02866799 Start date: November 2016. End date: February 2018 Protocol published 2017. Results not yet published Investigator: Alexandra Prados‐Torres (email: sprados.iacs@aragon.es)