Adam 2019.

Study name	OPtimising thERapy to Prevent Avoidable Hospital Admissions in the Multimorbid Older People (OPERAM)
Methods	Multi‐centre cluster‐RCT
Participants	Inclusion: hospitalised patients ≥ 70 years with ≥ 3 chronic medical conditions and concurrent use of ≥ 5 long‐term medications at 1 of 4 participating study centres Exclusion: inability to provide informed consent, direct admission to palliative care (< 24 hours after admission), has passed or will pass a systematic structured drug review during this hospitalisation or within last 2 months
Interventions	Intervention group: Systematic Tool to Reduce Inappropriate Prescribing (STRIP) intervention during initial hospital admission (index hospitalisation) or an equivalent situation for outpatients. STRIP intervention consists of 9 steps: (1) structured history‐taking of medication; (2) recording of medication and diagnoses in decision‐support software, (3) structured drug review based; (4) communication and discussion of structured drug review with prescribing physician; (5) shared decision‐making with patient; (6) optional revision based on new accumulating data during hospitalisation (e.g. new diagnoses, adverse drug reactions); (7) generation of GP report; (8) delivery of the report to the patient and to the GP; (9) follow‐up Control group: receive usual care and 1 questionnaire will be conducted by the intervention team in both arms, which is considered a sham intervention Patients will be followed up by phone at 2, 6, and 12 months
Outcomes	Drug compliance using Morisky Mediation Adherence Questionnaire (MMAS‐8), healthcare utilisation, hospitalisations, mortality, adverse medical events (including adverse drug events and number of falls), quality of life using EQ‐5D
Starting date	Start date: December 2016. Anticipated completion: 2019
Contact information	Professor Nicolas Rodondi (email: nicolas.rodondi@insel.ch)
Notes	NCT02986425 Protocol published 2019. Communication with investigator; results expected early 2020