Table 3.

Extended-Release Formulations: Methylphenidate

Drug	Formulation(s)	Dose range	Clinical tips
Cotempla XR ODT®	8.6, 17.3, and 25.9 mg tablets	• Starting dose: 6–17 years old: 17.3 mg • Given QD in am • Dose can be increased by 8.6 to 17.3 mg/day weekly • Dose above 51.8 have not been studied	• Onset of response within 1 hour • Duration of response 8–12 hours postdose • Can be swallowed without water
Quillivant XR®	25 mg/5 mL suspension	• Starting dose: 6 years and older: 10–20 mg (2–4 mL) • Given QD in am • Concentration = 25 mg/5 mL • Dose can be increased by 10–20 mg/day weekly • Max dose 60 mg/day	• Onset of response 45 minutes • Duration of response 10–12 hours postdose
Quillichew ER®	20 and 30 mg scored tablets 40 mg tablets	• Starting dose: 6 years and older: 10–20 mg • Given QD in am • Dose can be increased by 10–20 mg/day weekly • Doses above 60 mg/day have not been studied	• Onset of response within 1 hour • Duration of response 8–10 hours postdose • Can be chewed or swallowed whole
Daytrana®	10, 15, 20, and 30 mg patch	• Starting dose: 6 years and older: 10 mg patch • Given QD in am • Dose can be increased to next patch size weekly • Max dose 30 mg patch/day	• Onset of response within 2 hours • Duration of response depends on wear time • Maximum wear time 9 hours • Response may persist for 2–3 hours after patch removal • Lag time to response in the morning may necessitate the use of a morning dose of immediate-release methylphenidate
Aptensio XR®	10, 15, 20, 30, 40, 50, and 60 mg capsules	• Starting dose 10 mg • Given QD in the am • Increase by 10 mg/day weekly • Max dose: 60 mg/day	• Onset of response within 1 hour • Duration of response 12 hours postdose • Capsule can be opened, and contents can be mixed with a small amount of food (applesauce, yogurt, etc.)
Adhansia XR®	25, 35, 45, 55, 70, and 85 mg capsules	• Starting dose: 6 years and older: 25 mg • Given QD in am • Dose can be increased by 10 to 15 mg/day weekly • Dose above 70 mg in pediatric patients and above 85 mg in adults result in greater incidence of adverse events	• Onset of response within 1 hour • Duration of response 16 hours postdose • Achieves steady state plasma level in 3 days • Capsule can be opened, and contents can be mixed with a small amount of food (applesauce, yogurt, etc.)
Jornay PM®	20, 40, 60, and 80 mg capsules	• Starting dose: 6 years and older: 20 mg • Given QD in the evening between 6:30 and 9:30 pm • Dose can be increased by 20 mg/day weekly • Doses between 20 and 80 mg well tolerated • Dose above 100 mg has not been studied	• Onset of response within 8–10 hours after administration • Duration of response 22–24 hours postdose (10–12 hours after delayed onset) • Capsule can be opened, and contents can be mixed with a small amount of food (applesauce, yogurt, etc.)

All listed formulations are dl-methylphenidate.

ODT, orally dissolving tablets.