Table 5.
Substitution Tables Methylphenidate Extended-Release Formulations
| Drug | Conversiona | Comments |
|---|---|---|
| Cotempla XR ODT | 8.6 mg -> 10 MPH ER or 5 mg MPH IR BID 17.3 mg -> 20 MPH ER or 10 mg MPH IR BID 25.9 -> 30 MPH ER or 15 mg MPH IR BID |
8.6, 17.3, and 25.9 mg tablets contain the same amount of MPH (base equivalent) found in other 10, 20, and 30 mg ER MPH formulations |
| Quillivant XR | 2 mL -> 10 mg MPH ER or 5 mg MPH IR BID 4 mL -> 20 mg MPH ER or 10 mg MPH IR BID 6 mL -> 30 mg MPH ER or 15 mg MPH IR BID 8 mL -> 40 MPH ER or 20 mg MPH IR BID |
Studies in adults suggest that Quillivant XR® 60 is bioequivalent to two 30 mg doses of dl-MPH IR oral solution. (Concentration = 25 mg/5 mL) |
| Quillichew ER | 20 mg -> 20 mg MPH ER or 10 mg MPH IR BID 30 mg -> 20 mg MPH ER or 15 MPH IR BID 40 mg -> 40 mg MPH ER or 20 mg MPH IR BID |
A 40 mg dose of QuilliChew ER is comparable to two 20 mg doses of IR MPH given 6 hours apart; however, the peak concentration (−20%) and the overall bioavailability (−11%) are slightly lower when QuilliChew ER is administered |
| Daytrana | 10 mg patch -> 10 mg MPH ER or 5 mg MPH IR BID | 10 mg patch delivers 1.1 mg/h with a delayed onset |
| Aptensio XR | 10 mg -> 10 mg of MPH ER or 5 mg MPH IR BID | Aptensio® XR® appears comparable to other MPH oral dosage formulations with an onset of action of 1 hour following administration and duration of up to 12 hours |
| Adhansia XR | 25 mg -> 5 mg MPH IR TID 100 mg -> 20 mg MPH IR TID |
When Adhansia 100 mg qam is compared to MPH IR 20 mg TID, Adhansia XR exhibits a significantly higher initial peak (Cmax 22% higher) |
| Jornay PM | 20 mg -> 4 mg MPH IR TID given in the am 40 mg -> 8 mg MPH IR TID given in the am 60 mg -> 12 mg MPH IR PO TID given in the am 80 mg -> 16 mg MPH IR PO TID given in the am 100 mg -> 20 mg MPH IR PO TID given in the am |
After a delayed onset of action, 100 mg comparable to 20 mg TID |
a
Approximate substitutions for emergency use only. When time allows, start new formulation based on original recommendations.
ER, extended release; IR, immediate release; MPH, methylphenidate.