Table 6.
Substitution Tables Amphetamine Extended-Release Formulations
| Drug | Conversiona | Comments |
|---|---|---|
| Adzenys XR-ODT | 3.1 mg -> 5 mg MAS XR or 2.5 mg MAS IR BID 6.3 mg -> 10 mg MAS XR or 5 mg MAS IR BID 9.4 mg -> 15 mg MAS XR or 7.5 mg MAS IR BID 12.5 mg -> 20 mg MAS XR or 10 mg MAS IR BID 15.7 mg -> 25 mg MAS XR or 12.5 mg MAS IR BID 18.8 mg -> 30 mg MAS XR or 15 mg MAS IR BID |
Adzenys XR-ODT 18.8 mg tablet is equivalent to 30 mg of Adderall XR® (MAS ER) or 15 mg MAS IR BID |
| Adzenys ER | 2.5 mL -> 5 mg MAS XR or 2.5 mg MAS IR BID 5 mL -> 10 mg MAS XR or 5 mg MAS IR BID 7.5 mL -> 15 mg MAS XR or 7.5 mg MAS IR BID 10 mL -> 20 mg MAS XR or 10 mg MAS IR BID 12.5 mL -> 25 mg MAS XR or 12.5 mg MAS IR BID 15 mL -> 30 mg MAS XR or 15 mg MAS IR BID |
18.8 mg (15 mL) is equivalent to 30 mg Adderall XR (MAS ER) or 15 mg MAS IR BID |
| Dynavel XR | 2.5 mL -> 10 mg MAS XR or 5 mg MAS IR BID 5 mL -> 20 mg MAS XR or 10 mg MAS IR BID 7.5 mL -> 30 mg MAS XR or 15 mg MAS IR BID |
1 mL of Dynavel XR suspension contains 2.5 mg of MAS base 10 mg of Adderall XR contains 6.3 mg MAS base |
| Vyvanse Capsule | 30 mg -> 10 mg MAS XR or 5 mg MAS IR BID 50 mg -> 20 mg MAS XR or 10 mg MAS IR BID 70 mg -> 30 mg MAS XR or 15 mg MAS IR BID |
Studies indicate that AUC and Cmax for d-amphetamine from 75 mg NRP 104 (LDX) were comparable to (d-l-amphetamine) from 35 mg Adderall XR. The data also show d-amphetamine equivalence for AUC for 75 mg NRP 104 (LDX) and 30 mg Dexedrine, while peak exposure was 48% higher from NRP 104 than from Dexedrine. |
| Vyvanse Chewable Tablet | 30 mg -> 10 mg MAS XR or 5 mg MAS IR BID 50 mg -> 20 mg MAS XR or 10 mg MAS IR BID 70 mg -> 30 mg MAS XR or 15 mg MAS IR BID |
Studies indicate that AUC and Cmax for d-amphetamine from 75 mg NRP 104 (LDX) were comparable to (d-l-amphetamine) from 35 mg Adderall XR. The data also show d-amphetamine equivalence for AUC for 75 mg NRP 104 (LDX) and 30 mg Dexedrine, while peak exposure was 48% higher from NRP 104 (LDX) than from Dexedrine. |
| Mydayis | 37.5 mg -> 25 MAS XR +12.5 MAS IR 8 hours later | Because of long duration of action, substitution requires two doses as noted |
a
Approximate substitutions for emergency use only. When time allows, start new formulation based on original recommendations.
ER, extended release; IR, immediate release; LDX, lisdexamfetamine; MAS, mixed amphetamine salts.