Table 2.
Pharmacokinetic Parameters Calculated Based on Serum T3 Data Points Obtained from LT3- or PZL-Treated Rats
| Drug | Cmax(ng/mL) | tmax(h) | AUC (ng-h/mL) | t1/2(h) |
|---|---|---|---|---|
| Raw data | ||||
| LT3 | 1.5 ± 0.30 | 3.4 ± 0.94 | 11.5 ± 2.0 | 4.9 ± 0.70 |
| PZL | 1.1 ± 0.25# | 9.0 ± 3.6** | 9.2 ± 2.1## | 7.7 ± 0.85*** |
| Baseline corrected data | ||||
| LT3 | 1.22 ± 0.30 | 3.5 ± 0.69 | 8.4 ± 2.0 | 4.9 ± 0.70 |
| PZL | 0.87 ± 0.24# | 9.0 ± 3.6* | 6.0 ± 1.9# | 7.7 ± 0.85** |
Entries are the mean ± SD of four animals. Parameters were calculated by averaging values obtained for each individual animal.
*
p ≤ 0.05 vs. LT3; **p ≤ 0.01 vs. LT3; ***p ≤ 0.001 vs. LT3; #p = 0.06 vs. LT3; ##p < 0.08.
LT3, liothyronine; PZL, poly-zinc-liothyronine; Cmax, maximum serum concentration; tmax, time of maximum serum concentration; AUC, area under the curve; t1/2, plateau time; SD, standard deviation.