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. Author manuscript; available in PMC: 2020 May 8.
Published in final edited form as: Biochemistry. 2020 Jan 30;59(5):647–651. doi: 10.1021/acs.biochem.9b01036

Figure 3.

Figure 3.

Effect of N-terminal H3 tail mutations on KDM5A activity. (a) Impact of the PHD1 effector ligand on demethylase activity. KDM5A1–797 activity for 21mer H3K4me3 WT and mutant peptides in the absence and presence of 20 μM effector (unmodified 10mer peptide). Error bars represent the standard error of the mean of two independent experiments. (b) Sequence alignment of H3 tail methylated lysine residues. Amino acids are color coded as follows: blue, R/K/H; orange, T/S; green, Q; white, A/G; black, P; and gray, L/V/I.