TABLE IV. Socio-demographic profile and clinical characteristics of 106 patients with drug resistant tuberculosis from São Paulo State.
| Characteristics | MDR-TB (n = 90) | pre-XDR-TB (n = 11) | XDR-TB (n = 5) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2016 | 2017 | n | % | 2016 | 2017 | n | % | 2016 | 2017 | n | % | ||
| Gender (n = 106) | |||||||||||||
| Male | 35 | 30 | 65 | 72.2 | 4 | 1 | 5 | 45.5 | 2 | - | 2 | 40.0 | |
| Female | 12 | 13 | 25 | 27.8 | 5 | 1 | 6 | 54.5 | 2 | 1 | 3 | 60.0 | |
| Ethnicity (n = 99) | |||||||||||||
| White | 16 | 19 | 35 | 42.2 | 3 | 1 | 4 | 36.4 | 3 | 1 | 4 | 80.0 | |
| Brown | 21 | 14 | 35 | 42.2 | 4 | 1 | 5 | 45.5 | 1 | - | 1 | 20.0 | |
| Black | 6 | 7 | 13 | 15.6 | 2 | - | 2 | 18.1 | - | - | - | - | |
| No information | 4 | 3 | 7 | - | - | - | - | - | - | ||||
| Age (years) (n = 105) | |||||||||||||
| 15-29 | 11 | 10 | 21 | 23.6 | 3 | - | 3 | 27.3 | - | 1 | 1 | 20.0 | |
| 30-59 | 31 | 22 | 53 | 59.6 | 5 | 2 | 7 | 63.6 | 3 | - | 3 | 60.0 | |
| ≥ 60 | 5 | 10 | 15 | 16.8 | 1 | - | 1 | 9.1 | 1 | - | 1 | 20.0 | |
| No information | - | 1 | 1 | - | - | - | - | - | - | ||||
| Mean ± SD | 44.76 ± 15.10 | 39.45 ± 12.93 | 45 ± 13.81 | ||||||||||
| Education level (years) (n = 86) | |||||||||||||
| 1 a 7 | 22 | 13 | 35 | 48,6 | 4 | 1 | 5 | 45.5 | 3 | - | 3 | 60.0 | |
| 8 a 14 | 15 | 21 | 36 | 50.0 | 3 | 1 | 4 | 36.4 | 1 | 1 | 2 | 40.0 | |
| 15 or more | - | 1 | 1 | 1.4 | 2 | - | 2 | 18.1 | - | - | - | - | |
| No information | 10 | 8 | 18 | - | - | - | |||||||
| TB presentation (n = 104) | |||||||||||||
| Pulmonary | 44 | 40 | 84 | 95.4 | 9 | 2 | 11 | 100.0 | 4 | 1 | 5 | 100.0 | |
| Extrapulmonary | 2 | - | 2 | 2.3 | - | - | - | - | - | - | - | ||
| Pulmonary + Extrapulmonary | - | 2 | 2 | 2.3 | - | - | - | - | - | - | - | ||
| No information | 1 | 1 | 2 | - | - | - | - | - | - | ||||
| HIV status (n = 99) | |||||||||||||
| Negative | 36 | 35 | 71 | 83.5 | 7 | 1 | 8 | 80.0 | 2 | 1 | 3 | 75.0 | |
| Positive | 5 | 4 | 9 | 10.6 | - | - | - | - | - | - | - | - | |
| Not done | 3 | 2 | 5 | 5.9 | 2 | - | 2 | 20.0 | 1 | - | 1 | 25.0 | |
| No information | 3 | 2 | 5 | - | 1 | 1 | 1 | - | 1 | ||||
| Comorbidities (n = 102) | |||||||||||||
| Alcohol abuse | 2 | 1 | 3 | 3.4 | - | - | - | - | - | - | - | - | |
| Drug addiction | 3 | 1 | 4 | 4.6 | - | 1 | 1 | 10.0 | - | - | - | - | |
| Smoking | 9 | 7 | 16 | 18.4 | 1 | - | 1 | 10.0 | - | - | - | - | |
| Diabetes mellitus | 4 | 6 | 10 | 11.5 | 1 | - | 1 | 10.0 | - | - | - | - | |
| Alcohol abuse, diabetes mellitus, drug addiction, smoking | 17 | 6 | 23 | 26.4 | 2 | - | 2 | 20.0 | 2 | - | 2 | 40.0 | |
| None | 8 | 14 | 22 | 25.3 | 4 | - | 4 | 40.0 | 2 | 1 | 3 | 60.0 | |
| Others | 3 | 6 | 9 | 10.4 | - | 1 | 1 | 10.0 | - | - | - | - | |
| No information | 1 | 2 | 3 | 1 | - | 1 | - | - | - | ||||
| Previous TB (n = 104) | |||||||||||||
| No | 20 | 15 | 35 | 39.8 | 3 | 2 | 5 | 45.5 | - | 1 | 1 | 20.0 | |
| Yes | 26 | 27 | 53 | 60.2 | 6 | - | 6 | 54.5 | 4 | - | 4 | 80.0 | |
| No information | 1 | 1 | 2 | - | - | - | - | - | - | ||||
| Treatment group (n = 104) | |||||||||||||
| New case | 20 | 15 | 35 | 39.8 | 3 | 2 | 5 | 45.5 | - | 1 | 1 | 20.0 | |
| Relapse | 8 | 13 | 21 | 23.9 | - | - | - | - | - | - | - | - | |
| Retreatment | 18 | 14 | 32 | 36.3 | 6 | - | 6 | 54.5 | 4 | 0 | 4 | 80.0 | |
| No information | 1 | 1 | 2 | - | - | - | - | - | - | ||||
| Treatment outcome (n = 92) | |||||||||||||
| Successful | 29 | 30 | 59 | 76.6 | 4 | 1 | 5 | 50.0 | 2 | 1 | 3 | 60.0 | |
| Unsuccessful | 11 | 7 | 18 | 23.4 | 4 | 1 | 5 | 50.0 | 2 | - | 2 | 40.0 | |
| No information | 7 | 6 | 13 | 1 | - | 1 | - | - | - | ||||
| Death (n = 98) | |||||||||||||
| No | 38 | 35 | 73 | 88.0 | 5 | 2 | 7 | 63.6 | 3 | 1 | 4 | 80.0 | |
| Yes | 6 | 4 | 10 | 12.0 | 3 | - | 4 | 36.4 | 1 | - | 1 | 20.0 | |
| No information | 3 | 4 | 7 | 1 | - | - | - | - | - | ||||
TB: tuberculosis; MDR: multidrug resistant; XDR: extensively drug resistant.