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The figure represents FACS analysis of changes in circulating immune cells from a single patient at the RPTD over 3 cycles. In each cycle, samples were drawn on days 1, 3, 8, 15, 17, 29 (day 1 of next cycle), and ended on day 85 (day 1 of cycle 4). A peak in the dendritic cell maturation was observed at 48 hours (days 3, 31, 59, 87), followed by activation of CD8 T cells after 7 days (days 8, 36, 64), a process repeated with a dose of pelareorep delivered every 28 days.
