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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Mol Cancer Ther. 2020 Mar 10;19(5):1148–1156. doi: 10.1158/1535-7163.MCT-19-1117

Figure 4.

Figure 4

Flow cytometry analysis of bivariate (CD8+ CD70+) cell population in a representative patient’s PBMC at pre (day 1 prior to pelareorep administration) and day 8 (168 hours post dose). Cells were labelled with PE-CD8 (eBioscience #12–0088-80) and efluro660-CD70 (e Biosciences # 50–0709) antibodies post live dead (FVD eFluro780 # 65–0865) staining. The CD8 positive cell population were gated out of the live cell population. The CD8+ cells were further selected for CD8 CD70+ and CD8 CD70− population (indicated in square boxes). The CD8 positive cell population with low CD70 expression was carefully excluded from the analysis. The D8 CD8CD70+ population increases from 2.8% to 45.1%.