Stevens 2006.

Methods	Randomised, cross‐over study, 6 months subsequent phases of either home of hospital chemotherapy
Participants	2 to 16 year age group 29 children with acute lymphoblastic leukaemia (ALL) in the year prior to enrolment in study 15 allocated to home and then hospital chemotherapy and 14 vice versa Total 23 children received allocated treatment 6 children discontinued intervention or relapsed
Interventions	Comparison of home‐based with hospital‐based chemotherapy At home, chemotherapy administered by a trained nurse
Outcomes	Child's quality of life (QOL) Effects on parental caregivers Adverse effects Costs Data assessed at baseline, 3 months (postphase 1), 6 months (postphase 1), 3 months (postphase 2) and 6 months (postphase 2)
Notes	Cross‐over study with no time gap between cross‐over of two study arms
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: " Using a table of random numbers, eligible children were randomly assigned by the study site manager to either the hospital (standard care) or home (treatment) chemotherapy group for phase 1 (6 months)."
Allocation concealment (selection bias)	Unclear risk	Comment: the allocation concealment is not mentioned.
Blinding (performance bias and detection bias) All outcomes	High risk	Comment: The study method implies that blinding of neither participants nor clinicians was possible.
Blinding of participants and personnel (performance bias) All outcomes	High risk	As above
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Comment: Not mentioned whether data were analysed by independent clinicians blinded to the outcome assessment.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Comment: outcome data were reported for all participants.
Selective reporting (reporting bias)	Low risk	Comment: outcome data were presented for all outcomes reported as measured.
Other bias	Low risk	Comment: none were identified.