10. Bivariate analysis for on study mortality in chemotherapy trials.
| On study mortality for chemotherapy patients | N included | ESA versus control Unadjusted HR (95% confidence interval) | ESA versus control Adjusted HR (95% confidence interval) | P value LR‐Test* |
| Total | 10441 | 1.10 (95% CI 0.98‐1.24) | ‐ | ‐ |
| Hb at baseline (continuous) | 9945 | 1.10 (95% CI 0.98‐1.25) | 1.12 (95% CI 0.99‐1.26) | 0.0000 |
| Hb at baseline (categorical 1) | 9945 | 1.10 (95% CI 0.98‐1.25) | 1.12 (95% CI 0.99‐1.26) | 0.0000 |
| Hb at baseline (categorical 2) | 9945 | 1.10 (95% CI 0.98‐1.25) | 1.12 (95% CI 0.99‐1.26) | 0.0000 |
| Tumor (categorical 1) | 10399 | 1.10 (95% CI 0.97‐1.24) | 1.10 (95% CI 0.97‐1.24) | 0.0049 |
| Tumor (categorical 2) | 10399 | 1.10 (95% CI 0.97‐1.24) | 1.10 (95% CI 0.97‐1.24) | 0.0000 |
| Sex | 10441 | 1.10 (95% CI 0.98‐1.24) | 1.10 (95% CI 0.97‐1.24) | 0.0000 |
| Age (continuous) | 10430 | 1.10 (95% CI 0.98‐1.24) | 1.10 (95% CI 0.98‐1.24) | 0.0000 |
| Age (categorical) | 10430 | 1.10 (95% CI 0.98‐1.24) | 1.10 (95% CI 0.98‐1.24) | 0.0002 |
| Hct (continuous) | 7849 | 1.11 (95% CI 0.98‐1.26) | 1.12 (95% CI 0.98‐1.27) | 0.0000 |
| Hct (categorical) | 7849 | 1.11 (95% CI 0.98‐1.26) | 1.12 (95% CI 0.98‐1.27) | 0.0000 |
| Baseline serum EPO (continuous) | 3959 | 0.99 (95% CI 0.82‐1.20) | 0.99 (95% CI 0.82‐1.19) | 0.2936 |
| Baseline serum EPO (categorical) | 3959 | 0.99 (95% CI 0.82‐1.20) | 0.98 (95% CI 0.81‐1.19) | 0.0651 |
| ECOG (0 vs 1 vs 2 vs 3 vs 4) | 8057 | 1.12 (95% CI 0.98‐1.28) | 1.11 (95% CI 0.97‐1.27) | 0.0000 |
| ECOG (0,1,2 vs 3,4) | 8057 | 1.12 (95% CI 0.98‐1.28) | 1.12 (95% CI 0.98‐1.29) | 0.0000 |
| BMI (categorical) | 8882 | 1.08 (95% CI 0.94‐1.23) | 1.09 (95% CI 0.95‐1.24) | 0.0000 |
| History of thromboembolic events | 6667 | 1.11 (95% CI 0.96‐1.28) | 1.11 (95% CI 0.96‐1.28) | 0.0658 |
| History of cardiovascular events | 7369 | 1.11 (95% CI 0.96‐1.28) | 1.10 (95% CI 0.96‐1.27) | 0.0394 |
| History of hypertension | 6667 | 1.11 (95% CI 0.96‐1.28) | 1.11 (95% CI 0.96‐1.28) | 0.7143 |
| History of diabetes mellitus | 5579 | 1.09 (95% CI 0.94‐1.26) | 1.09 (95% CI 0.94‐1.27) | 0.0802 |
| Geographical region [region_cat] | 10053 | 1.09 (95% CI 0.97‐1.23) | 1.09 (95% CI 0.97‐1.24) | 0.2767 |
| Metastatic vs non‐metastatic | 8956 | 1.16 (95% CI 1.02‐1.32) | 1.15 (95% CI 1.01‐1.31) | 0.0000 |
| Time from cancer diagnosis to randomization | 3114 | 1.06 (95% CI 0.85‐1.31) | 1.06 (95% CI 0.85‐1.32) | 0.6775 |
*This test compares the adjusted with the unadjusted model. It takes into account the entire model, not only the overall hazard ratio.