23. Overall survival in chemotherapy trials, tests for interaction, univariate and multivariate models.

Overall survival in chemotherapy trials	Bivariate ESA versus control			Multivariate ESA versus control
Interaction term	ESA*sex			ESA*sex
Adjusted for	‐			age, sex, Hb, tumor type
Patients excluded		‐			‐
Patients included		n = 10441			n = 9892
ESA versus control	HR	95% CI	P*	HR	95% CI	P*
Sex
Male	0.96	0.87‐1.06	0.0370	0.97	0.87‐1.07	0.0362
Female	1.10	1.01‐1.21		1.12	1.02‐1.22
Overall result, unadjusted	1.04	0.97‐1.11	‐	1.04	0.97‐1.11	‐

*P value LR test comparing model with and without interaction term