30. Survival at predefined time points in chemotherapy trials, long term follow up studies only*.
On study mortality data set | Overall survival data set | |||||
Time after date of randomization | Deaths | ESA versus control HR (95% CI)** | P value | Deaths | ESA versus control HR (95% CI)* | P value |
At 4 months | 499 | 1.14 (95% CI 0.95‐1.36) | 0.153 | 604 | 1.14 (95% CI 0.97‐1.34) | 0.119 |
At 8 months | 658 | 1.18 (95% CI 1.01‐1.37) | 0.040 | 1346 | 1.01 (95% CI 0.91‐1.13) | 0.842 |
At 12 months | 738 | 1.20 (95% CI 1.03‐1.39) | 0.016 | 1952 | 1.03 (95% CI 0.94‐1.13) | 0.527 |
At 24 months | ‐ | ‐ | ‐ | 2594 | 1.05 (95% CI 0.97‐1.14) | 0.191 |
At 36 months | ‐ | ‐ | ‐ | 2789 | 1.04 (95% CI 0.97‐1.12) | 0.290 |
At 60 months | ‐ | ‐ | ‐ | 2878 | 1.05 (95% CI 0.98‐1.13) | 0.182 |
*6509 patients from the chemotherapy treatment population stemming from trials that were designed for long term follow up were under observation. ** Based on Cox fixed‐effects model stratified by study