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. 2009 Jul 8;2009(3):CD007303. doi: 10.1002/14651858.CD007303.pub2

Osterborg 2002.

Methods randomized controlled trial, placebo‐controlled
Participants n = 349, multiple myeloma, Non‐Hodgkin lymphoma, chronic lymphocytic lymphoma; concomitant treatment: chemotherapy
Interventions drug = Epoetin beta
dose = 150 IU/kg sc TIW
hb‐target = 13‐14 g/dL
planned ESA duration = 16 weeks
Outcomes Primary: transfusion free survival; secondary: Hb response, time to response, number of blood transfusions, QoL, safety
Notes study number = 77914
Risk of bias
Bias Authors' judgement Support for judgement
Adequate sequence generation? Unclear risk randomization program
Allocation concealment? Low risk central randomization