Savonije 2005.

Methods	randomized controlled trial, not placebo‐controlled
Participants	n = 315, non‐small cell lung cancer, gastrointestinal, gynecological, colorectal, small cell lung cancer, other cancer; concomitant treatment: chemotherapy
Interventions	drug = Epoetin alpha dose = 10000 IU sc TIW hb‐target = 13‐14 g/dL planned ESA duration = during chemotherapy
Outcomes	Primary: transfusion; secondary: Hb, tumor response, QoL, survival
Notes	study number = 70724
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	randomization center generates a list of subject numbers and randomly allocate numbers to the two treatment groups using a block size of six
Allocation concealment?	Low risk	central randomization