On study mortality all cancer patients

Bivariate ESA versus control

Multivariate ESA versus control

Multivariate ESA versus control

Multivariate ESA versus control

Interaction term

ESA*HTX

ESA*HTX

ESA*HTX

ESA*HTX

Model adjusted for

‐

age, sex, Hb, tumor type

age, sex, Hb, tumor type and ECOG

age, sex, Hb, tumor type and serum EPO

Patients included

n = 9620

n = 9467

n = 7999

n = 4281

HR

95% CI

P*

HR

95% CI

P*

HR

95% CI

P*

HR

95% CI

P*

History of thromboembolic events (HTX)

Yes

0.80

0.52‐1.23

0.0605

0.77

0.50‐1.19

0.0440

0.75

0.48‐1.18

0.0338

0.48

0.25‐0.93

0.0129

No

1.23

1.09‐1.39

1.22

1.08‐1.38

1.25

1.10‐1.42

1.13

0.94‐1.34

Missing / not reported

1.09

0.87‐1.35

‐

omitted

omitted

‐

omitted

omitted

‐

omitted

omitted

‐

Overall, unadjusted

1.20

1.07‐1.34

‐

1.20

1.07‐1.34

‐

1.21

1.07‐1.36

‐

1.10

0.93‐1.30

‐