On study mortality all cancer patients

Bivariate ESA versus control HCT*ESA

Multivariate ESA versus control HCT*ESA

Multivariate ESA versus control HCT*ESA

Multivariate ESA versus control HCT*ESA

Adjusted for

‐

age, sex, Hb, tumor type

age, sex, Hb, tumor type and tumor stage

age, sex, Hb, tumor type and ECOG

Patients included

n = 11036

n = 10972

n = 9714

n = 7686

HR

95% CI

P*

HR

95% CI

P*

HR

95% CI

P*

HR

95% CI

P*

Hct at baseline

< 23.5%

2.19

1.35‐3.55

0.0110

2.13

1.30‐3.48

0.0191

1.92

1.13‐3.24

0.1220

2.85

1.47‐5.53

0.0254

23.5‐29.4%

0.96

0.78‐1.17

0.96

0.79‐1.18

1.00

0.80‐1.24

1.00

0.80‐1.26

29.4‐35.3%

1.17

0.99‐1.39

1.15

0.97‐1.37

1.23

1.02‐1.48

1.17

0.96‐1.42

35.3‐41.2%

1.41

1.12‐1.76

1.39

1.10‐1.74

1.37

1.08‐1.72

1.39

1.07‐1.79

> 41.2%

1.12

0.73‐1.70

1.15

0.76‐1.76

1.15

0.75‐1.75

1.15

0.71‐1.89

Missing

1.09

0.76‐1.55

‐

omitted

‐

omitted

‐

omitted

‐

Overall, unadjusted

1.18

1.06‐1.32

‐

1.18

1.06‐1.32

‐

1.22

1.09‐1.36

‐

1.20

1.06‐1.35

‐