Overall survival in chemotherapy trials

Bivariate ESA versus control

Multivariate ESA versus control

Multivariate ESA versus control

Multivariate ESA versus control

Multivariate ESA versus control

Interaction term

ESA*sex

ESA*sex

ESA*sex

ESA*sex

ESA*sex

Adjusted for

‐

age, sex, Hb, tumor type

age, sex, Hb, tumor type

age, sex, Hb, tumor type

age, sex, Hb, tumor type

Patients excluded

‐

‐

excluding breast cancer patients

excluding breast cancer and gynecological cancer patients

excluding breast cancer, gynecological cancer as well as prostate and testicular cancer patients

Patients included

n = 10441

n = 9892

n = 6257

n = 5205

5128

ESA versus control

HR

95% CI

P*

HR

95% CI

P*

HR

95% CI

P*

HR

95% CI

P*

HR

95% CI

P*

Sex

Male

0.96

0.87‐1.06

0.0370

0.97

0.87‐1.07

0.0362

0.97

0.87‐1.07

0.1571

0.97

0.87‐1.07

0.2071

0.97

0.87‐1.07

0.2169

Female

1.10

1.01‐1.21

1.12

1.02‐1.22

1.09

0.96‐1.23

1.07

0.94‐1.23

1.07

0.94‐1.23

Overall result, unadjusted

1.04

0.97‐1.11

‐

1.04

0.97‐1.11

‐

1.00

0.93‐1.08

‐

1.00

0.91‐1.07

‐

0.99

0.92‐1.08

‐