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. 2009 Jul 8;2009(3):CD007303. doi: 10.1002/14651858.CD007303.pub2

Cazzola 1995.

Methods randomized controlled trial, not placebo‐controlled
Participants n = 143, multiple myeloma, Non‐Hodgkin lymphoma; concomitant treatment: chemotherapy
Interventions drug = Epoetin beta
dose = a: 1000 IU sc 7x/week, b: 2000 IU sc 7x/week; c: 5000 IU sc 7x/ week; d: 10000 IU sc 7x/week
hb‐target = 11‐13 g/dL (MM), 11‐15 g/dL (NHL)
planned ESA duration = 8 weeks
Outcomes Primary: Hb response; secondary: Hb, Hct, reticulocytes, iron, ferritin, safety
Notes study number = 37653
Risk of bias
Bias Authors' judgement Support for judgement
Adequate sequence generation? Unclear risk randomization list
Allocation concealment? Low risk central randomization