Study	Reason for exclusion
Boada‐Rovira 2005	Not randomised, no placebo group. Case control pilot experimental study using donepezil.
Castane 2004	No control group. Study of 12 of a group of 49 people older than 40 with Down syndrome, 12 of whom had diagnosed dementia and who were given donepezil. Experimental cohort study.
Cipriani 2003	No control group. Correspondence article refers to Lott 2002, not a report of a randomised controlled trial, reports 3 cases of donepezil use in dementia in Down syndrome.
Heller 2003	No control group. Open label study of donepezil for the treatment of language deficits, in adults with Down syndrome, no dementia.
Heller 2004	No control group, open label pilot study of donepezil effects on language in children with Down syndrome.
Hemingway‐Eltomy 1999	No control group, case report of 3 cases of Down syndrome patients with dementia, treated with donepezil, report of adverse effects requiring discontinuation of therapy.
Johnson 2003	RCT. 12‐week double blind, placebo controlled study of effects of donepezil on cognitive functioning in Down syndrome but no dementia.
Kishnani 1999	No control group, case report studying donepezil in 4 patients with Down syndrome, 2 having dementia.
Kishnani 2001	No control group, expands on results of case report published previously (Kishnani 1999) and comments on (Hemingway‐Eltomy 1999).
Kondoh 2005a	No control group, case report of 2 cases with Down syndrome treated with donepezil, only one case had dementia.
Kondoh 2005b	Not randomised, no placebo group. Two groups (one with Down syndrome, one comprised of healthy volunteers, none with dementia) received donepezil. Experimental study (pharmacokinetics of donepezil).
Lott 2002	Not randomised, no placebo group. Donepezil was tested versus no treatment in people with Down syndrome who had dementia in a pilot study format.