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. 2020 May 8;15(5):e0232857. doi: 10.1371/journal.pone.0232857

Table 2. Adherence to the ERP.

ERP component Assessment of adherence Result
n (%)
n patients
1 Preadmission counselling ERP consultation 83 (86.5) 96
2 Preoperative optimization n.a. n.a. 96
3 Preoperative bowel preparation No mechanical bowel preparation in colonic surgery 60 (98.4) 611
4 Preoperative fasting n.a. n.a. 96
Carbohydrate loading Yes 67 (69.8) 96
5 Pre-anesthetic medication No sedative or anxiolytic premedication 88 (91.7) 96
6 Thromboprophylaxis Yes 95 (99.0) 96
7 Antimicrobial prophylaxis Yes 96 (100) 96
8 Standard anesthesia protocol n.a.
9 PONV prophylaxis In patients with PONV risk ≥ 20% 89 (94.7) 942
10 Laparoscopy and modifications of surgical access Planned laparoscopic operation 81 (84.4) 96
11 Nasogastric tubes No NGT after reversal of anesthesia 92 (95.8) 96
12 Preventing intraoperative hypothermia Yes 84 (87.5) 96
13 Perioperative fluid management Stop intravenous fluids ≤ POD 3 (provided removal of PCEA/PCIA)
  • All patients

  • CD < 2 POCs*


52 (54.7)
37 (63.8)*

953
58
14 Drain peritoneal cavity No abdominal drain in colonic surgery 50 (82.0) 611
15 Urinary catheter Removal urinary catheter per protocol: laparoscopic colon POD 1, open colon or rectum POD 3 (only after PCEA removal)
  • All patients

  • CD < 2 POCs*


69 (77.5)
50 (87.7)*

893,4,5
57
16 Ileus prevention n.a. n.a. 96
17 Multimodal opioid sparing postop analgesia8 PCEA in patients without coagulation disorders for whom open surgery was planned 8 (88.9) 96
18 Early nutrition Oral food POD 1 79 (84.9) 937
Oral food POD 2 83 (89.2) 933,7
Oral food POD 3 82 (90.1) 913,7
19 Postoperative glycemic control Glucose day profile in patients with diabetes 19 (95.0) 208
20 Early mobilization Out of bed POD 1 78 (83.9) 937
Out of bed POD 2 87 (93.6) 933,7
Out of bed POD 3 90 (98.9) 913,7
Overall adherence, mean (± SD) 87.9% (± 10.8)

CD: Clavien-Dindo severity grade; ERP: enhanced recovery program; n: number; n.a.: adherence was not assessed; NGT: nasogastric tube; PCEA: patient controlled epidural analgesia; PCIA: patient controlled intravenous analgesia; POCs: postoperative complications; POD: postoperative day; PONV: postoperative nausea and vomiting; SD: standard deviation; excluded from the analysis:

1rectal surgery (n = 35),

2missing data (n = 2),

3deceased patient (n = 1),

4no urinary catheter (n = 3),

5permanent catheter (n = 3),

6open surgery planned (n = 15) in patients with coagulation disorders (n = 6),

7ICU admission on the POD considered,

8no diabetes (n = 76); 8all patients received paracetamol, restrictive use of NSAIDs due to age and comorbidities;

*this subgroup is not included in the calculation of the overall adherence