Table 5. Overall and country specific prevalence and 95% confidence intervals for phenotypic interpretation of observed mutations in smears with interpretable results for all gene targets, by case treatment status.
| Case Treatment Status by Country | No Drug Resistance | Mono-Resistance | Multi-Drug Resistance | Poly-Resistance | Any Drug Resistant Smears | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Prevalence (%) | 95% CI | Prevalence (%) | 95% CI | Prevalence (%) | 95% CI | Prevalence (%) | 95% CI | Prevalence (%) | 95% CI | |
| Ghana | ||||||||||
| New | 111/125 (88.80) | 81.92, 93.74 | 13/125 (10.40) | 5.65, 17.13 | 1/125 (0.80) | 0.02, 4.38 | 0/125 (0.00) | 0.00, 2.91 | 14/125 (11.20) | 6.26, 18.08 |
| Unknown | 115/139 (82.73) | 75.41, 85.61 | 11/139 (7.91) | 4.02, 13.72 | 6/139 (4.32) | 1.60, 9.16 | 7/139 (5.04) | 2.05, 10.10 | 24/139 (17.27) | 11.39, 24.59 |
| Total | 226/264 (85.61) | 80.78, 89.61 | 24/264 (9.09) | 5.91, 13.22 | 7/264 (2.65) | 1.07, 5.39 | 7/264 (2.65) | 1.07, 5.39 | 38/264 (14.39) | 10.39, 19.22 |
| Kenya | ||||||||||
| New | 287/297 (96.63) | 93.90, 98.37 | 4/297 (1.35) | 0.37, 3.41 | 1/297(0.34) | 0.01, 1.86 | 5/297 (1.68) | 0.55, 3.88 | 10/297 (3.37) | 1.63, 6.10 |
| Follow-up | 100/104 (96.15) | 90.44, 98.94 | 1/104 (0.96) | 0.02, 5.10 | 0/104 (0.00) | 0.00, 3.48 | 3/104 (2.88) | 0.60, 8.20 | 4/104 (3.85) | 1.06, 9.56 |
| Retreatment | 23/31 (74.19) | 55.39, 88.14 | 7/31 (22.58) | 9.59, 41.10 | 0/31 (0.00) | 0.00, 11.22 | 1/31 (3.23) | 0.08, 16.70 | 8/31 (25.81) | 11.86, 44.61 |
| Unknown | 1/2 (50.00) | 1.26, 98.74 | 0/2 (0.00) | 0.00, 84.19 | 0/2 (0.00) | 0.00, 84.19 | 1/2 (50.00) | 1.26, 98.74 | 1/2 (50.00) | 1.26, 98.74 |
| Total | 411/434 (94.70) | 92.15, 96.61 | 12/434 (2.76) | 1.44, 4.78 | 1/434 (0.23) | 0.01, 1.28 | 10/434 (2.30) | 1.11, 4.20 | 23/434 (5.30) | 3.39, 7.85 |
| Uganda | ||||||||||
| New | 90/107 (84.11) | 75.78, 90.46 | 12/107 (11.21) | 5.93, 18.77 | 3/107 (2.80) | 0.58, 7.98 | 2/107 (1.87) | 0.23, 6.59 | 17/107 (15.89) | 9.54, 24.22 |
| Follow-up | 17/18 (94.44) | 72.71, 99.86 | 0/18 (0.00) | 0.00, 18.53 | 1/18 (5.56) | 0.14, 27.29 | 0/18 (0.00) | 0.00, 18.53 | 1/18 (5.56) | 0.14, 27.29 |
| Retreatment | 0/1 (0.00) | 0.00, 97.50 | 0/1 (0.00) | 0.00, 97.50 | 0/1(0.00) | 0.00, 97.50 | 1/1 (100.00) | 2.50, 100.00 | 1/1 (100.00) | 2.50, 100.00 |
| Unknown | 1/1 (100) | 2.50, 100.00 | 0/1 (0.00) | 0.00, 97.50 | 0/1(0.00) | 0.00, 97.50 | 0/1 (0.00) | 0.00, 97.50 | 0/1(0.00) | 0.00, 97.50 |
| Total | 108/127 (85.04) | 77.63, 90.75 | 12/127 (9.45) | 4.98, 15.92 | 4/127 (3.15) | 0.86, 7.87 | 3/127 (2.36) | 0.49, 6.75 | 19/127 (14.96) | 9.25, 22.37 |
| Zambia | ||||||||||
| Unknown | 37/45 (82.22) | 67.95, 92.00 | 3/45 (6.67) | 1.40, 18.27 | 4/45 (8.89) | 2.48, 21.22 | 1/45 (2.22) | 0.06, 11.77 | 8/45 (17.78) | 8.00, 32.05 |
| Total | 37/45 (82.22) | 67.95, 92.00 | 3/45 (6.67) | 1.40, 18.27 | 4/45 (8.89) | 2.48, 21.22 | 1/45 (2.22) | 0.06, 11.77 | 8/45 (17.78) | 8.00, 32.05 |
| Overall | ||||||||||
| New | 488/529 (92.25) | 89.63, 94.38 | 29/529 (5.48) | 3.70, 7.78 | 5/529 (0.95) | 0.31, 2.19 | 7/529 (1.32) | 0.53, 2.71 | 41/529 (7.75) | 5.62, 10.37 |
| Follow-up | 117/122 (95.90) | 90.69, 98.66 | 1/122 (0.82) | 0.02, 4.48 | 1/122 (0.82) | 0.02, 4.48 | 3/122 (2.46) | 0.51, 7.02 | 5/122 (4.10) | 1.34, 9.31 |
| Retreatment | 23/32 (71.88) | 53.25, 86.25 | 7/32 (21.88) | 9.28, 39.97 | 0/32 (0.00) | 0.00, 10.89 | 2/32 (6.25) | 0.77, 20.81 | 9/32 (28.13) | 13.75, 46.75 |
| Unknown | 153/187 (81.82) | 75.53, 87.07 | 14/187 (7.49) | 4.15, 12.24 | 10/187 (5.35) | 2.59, 9.61 | 9/187 (4.81) | 2.22, 8.94 | 33/187 (17.65) | 12.47, 23.88 |
| Total | 782/870 (89.89) | 87.69, 91.81 | 51/870 (5.86) | 4.40, 7.64 | 16/870 (1.84) | 1.05, 2.97 | 21/870 (2.41) | 1.50, 3.67 | 88/870 (10.11) | 8.19, 12.31 |