Table 2.

Association of Baseline Anthropometric Measures and Biomarkers with 12-Month Change in NCP Volume. Based on Linear Regression Models Including Terms for Site, Age (over/under 75), Baseline Testosterone Level (over/under 200 ng/Dl), Baseline NCP volume, Predictor Variable, and Interaction of Predictor Variable with Treatment. P Values Not Adjusted for Multiple Comparisons

Predictor variable	Effect Estimate (Standard error)	95% CI	Nominal P value
HDL	0.31 (0.38)	−0.43, 1.06	0.40
HDL × treatment	−0.75 (0.65)	−2.03, 0.53	0.25
Non-HDL	0.034 (0.16)	−0.29, 0.35	0.84
Non-HDL × treatment	−0.83 (0.23)	−05.4, 0.37	0.71
D-dimer	−19.4 (9.93)	−39.1, 0.25	0.053
D-dimer × treatment	15.92 (14.98)	−13.74, 45.58	0.29
IL-6	−2.81 (2.78)	−8.32, 2.69	0.31
IL-6 × treatment	2.50 (3.32)	−4.07, 9.08	0.45
CRP	−1.48 (1.45)	−4.36, 1.39	0.31
CRP × treatment	1.30 (1.49)	−1.64, 4.25	0.38
Insulin	0.53 (0.36)	−0.66, 0.76	0.88
Insulin × treatment	−0.26 (0.57)	−1.40, 0.87	0.65
HbA1c	0.34 (9.00)	−17.5, 18.2	0.97
HbA1c × treatment	5.15 (11.88)	−18.82, 28.70	0.67
SHBG	0.24 (0.49)	−0.73, 1.21	0.63
SHBG × treatment	−0.83 (0.60)	−2.02, 0.36)	0.17
Weight	−0.44 (0.42)	−1.27, 0.40	0.30
Weight × treatment	0.80 (0.59)	−0.37, 1.97	0.18
Waist-hip ratio	−87.7 (93.2)	−272.2, 96.7	0.35
Waist-hip ratio × treatment	429.4 (131.4)	169.4, 689.5	0.0014

Abbreviations: CRP, C-reactive protein; HbA1c, hemoglobin A1C; HDL, high-density lipoprotein; IL-6, interleukin-6; IQR, interquartile range; SD, standard deviation; SHBG, sex hormone–binding globulin.