Table 1.
Case | Patient demographics | Time between hyperparathyroidism diagnosis and sarcoma diagnosis | Treatment of hyperparathyroidism | Sarcoma pathology | Sarcoma location |
1 (Spiro et al) | 46-year-old woman | 3 years | Parathyroidectomy | Dedifferentiated chondrosarcomaa | Distal left tibia |
2 (Spiro et al) | 34-year-old woman | 2 months | Parathyroidectomy | High-grade osteosarcoma | Mandible |
3 (Mercuri et al) | 56-year-old woman | Simultaneous diagnosis | Parathyroidectomy | High-grade osteosarcomab | Proximal left tibia |
4 (Vassilopoulou et al & Gagel et al) | 69-year-old woman | Not reported | Not reported | High-grade fibroblastic osteosarcomaa | Right proximal femur |
5 (Harell et al) | 50-year-old woman | 3 years | Untreated | Osteosarcoma | Mandible |
6 (Keen et al) | 66-year-old woman | Simultaneous diagnosis | Not reported | Low-grade chondrosarcoma arising from osteochondroma | Right scapula |
7 (Keen et al) | 36-year-old woman | Simultaneous diagnosis | Not reported | Low-grade chondrosarcoma arising from enchondroma | Left tibia |
8 (Gagel et al) | 15-year-old man | Simultaneous diagnosis | Not reported | Fibroblastic osteosarcomaa | Right femur and pelvis |
9 (Gagel et al) | 65-year-old woman | 3 years | Not reported | Fibroblastic osteosarcomab | Distal right femur |
10 (our case) | 22-year-old man | 3 years | Parathyroidectomy | Undifferentiated pleomorphic sarcomaa | Distal right femur |
Brown tumor or osteitis fibrosa cystica on pathology
Brown tumors on radiographs