Figure 2.

Flexibility of neuronal firing from CA1 pyramidal cells during sharp-wave ripples (SPW-ripples). (a) Unsupervised classification of individual sharp-wave ripple events clusters of similar local field potential signatures to be identified. The number of events in each group is indicated. Clusters of groups with topological similarities in the high-dimensional space are identified by colours in the inset scheme. (b) Single CA1 pyramidal cells were recorded juxtacellularly during sharp-wave ripples and their firing was grouped per cluster. Note different timing of the same cell in the orange and blue cluster indicated before. (c) Juxtacellular recorded cells are labelled for morphological identification with streptavidin, and classified as deep or superficial depending on their location within the calbindin-positive sublayer. (d) Distribution of the preferred firing phase during the sharp-wave from different clusters in deep and superficial cells. Note wider distribution in deep cells indicating more flexibility. Data from [86]. (Online version in colour.)