(1) Do interneurons receive phasic excitatory inputs during ripples?

(2) To what degree does replay reflect the increase in strength of existing patterns versus the encoding of new patterns enforced by sensory inputs?

(3) How does learning affect INT-PYR plasticity?

(4) How do theta and ripple sequences interact and to what extent do ripple sequences depend on theta?

(5) Are hippocampal and cortical ripples generated by the same mechanisms?

(6) Why are cortical ripples observed only in certain cortical areas (namely associational cortices)?

(7) How are hippocampal and cortical ripples synchronized?

(8) Are cortical ripples in different areas coupled with each other?

(9) Are cortical ripples necessary for memory consolidation?

(10) What is the role of cell-intrinsic properties in promoting ripple expression and recruitment?

(11) How does intrinsic excitability dictate sequential firing patterns, and does plasticity in neural excitability affect replay statistics?