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. Author manuscript; available in PMC: 2021 Mar 5.
Published in final edited form as: Cell. 2020 Feb 20;180(5):915–927.e16. doi: 10.1016/j.cell.2020.01.032

Figure 1: Overall functional impact of PCAWG variants:

Figure 1:

a) Functional impact distribution in non-coding (DNase hypersensitive sites averaged across multiple cell lines) regions: three peaks correspond to low-, medium-, and high-impact mutations. b) Correlation between the fraction of high- and medium-impact non-coding SNVs and the total mutational counts for lung adenocarcinoma cohort (left). Scatter plot for correlation coefficient (x-axis) and FDR-corrected p-value for various cancer cohorts (right). c) Log ratio between high-impact SV and SNV frequency in different cancer cohorts. Error bars correspond to variation within the cohort. See also supplement Fig. S1.