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. Author manuscript; available in PMC: 2021 Mar 5.
Published in final edited form as: Cell. 2020 Feb 20;180(5):915–927.e16. doi: 10.1016/j.cell.2020.01.032

Figure 4: Correlating functional burdening with subclonal information and patient survival:

Figure 4:

a) Subclonal ratio (early/late) for different categories of SNVs (coding and non-coding) based on their impact scores. Subclonal ratios for high-impact SNVs occupying distinct gene sets. b) Mutant tumor allele heterogeneity difference comparison between high-, and low-impact SNVs for coding (top) and non-coding (bottom) regions. c) Correlation between mean VAF and GERP score of different categories of variants on a pan-cancer level. d) Survival curves in CLL (left panel) and RCC (right panel) with 95% confidence intervals, stratified by mean GERP score. See also supplement Fig. S4.