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. 2020 May 5;11(18):1603–1617. doi: 10.18632/oncotarget.27558

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Copyright: Kumar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Structural representation of binding of (left to right) GSH, LZ6 (Chlorambucil), Quinacrine (QUN) and Ethacrynic acid (EAA) with GSTA1 [Blue ribbon representing A chain, green ribbon representing B chain of GSTA1 and ball and stick representing ligands].Bottom figure displays the ligands in the binding pocket with hydrophobicity and key interacting residues as generated by Discovery studio visualizer (B) Graph representing GST assay absorbance values of A549 and NCI H520 QC treated cell lysates (1 min, 30 min and 30-1 min). (C) Graph representing GST assay absorbance values of GST Control protein treated/incubated with different concentrations Of QC and EAA (1 min, 25 min and 25-1 min). (D) Graph representing the calculated percentage GST activity of cell lysates of A549 and NCI H520 with respect to their untreated controls. (E) Graph representing the calculated percentage GST activity of quinacrine and ethacrynic acid treated GST control protein with respect to the untreated sample.