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. 2020 May 4;13:383–393. doi: 10.2147/PRBM.S250945

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© 2020 Yisireyili et al.

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Stress increased gastric ROS production in mice. Immunohistochemistry, quantitative PCR, and ELISA were performed to check the expression levels of ROS biomarkers (Nox-4 and 8-OHdG) in the stomach of mice in the stress and control groups. The values for the stressed mice are presented relative to those for the control mice and are expressed as mean±SD (n=15). Student’s t-test was performed to analyze the differences between the stress and control groups. (A) Immunostaining of Nox4 in the stomach tissue (200× magnification, bar = 50 µm); (B) immunostaining of 8-OHdG in the stomach tissue (200× magnification, bar = 50 µm); (C) quantitative analysis of Nox-4 mRNA expression levels in stomach tissue. **P<0.001 compared with the control mice; (D) plasma concentrations of Nox-4 and (E) 8-OHdG in the control and stressed mice. **P<0.001 compared with the control mice.